Journal: bioRxiv
Article Title: Tissue stiffness mapping by light sheet elastography
doi: 10.1101/2023.12.09.570896
Figure Lengend Snippet: (A) Representative position tracking of a fluorescent bead in 1% agarose gel upon 10 Hz actuation. (B and C) 3D rendered phase and amplitude difference submerged in DMEM vs water at 37°C. (D) Fluid-structure interaction simulation model setup. (E) Simulation-predicted damping ratio as a function of the gel extrusion length. (F) Simulation-predicted damping ratio at varying viscosity and culture medium density with an extrusion length of 6.5 mm suggesting predominantly mass damping. (G and H) Simulation -predicted damping ratio at various agarose gel elastic moduli (G) and diameters (H) with an extrusion length of 6.5 mm. (I and J) Angle of rotation along central-boundary axis. (K) Angle of rotation along Y axis. (L) Increased deflection along Y axis. (M) Constant Y phase speed under different actuation frequencies suggesting non-dispersive shear wave propagation along the Y axis.
Article Snippet: To investigate the impact of system parameters (e.g., gel extrusion length) on the damping behavior and the source of DMEM-induced damping (i.e., mass vs. viscous damping), we conducted COMSOL fluid-structure interaction (FSI) simulations.
Techniques: Agarose Gel Electrophoresis, Viscosity, Shear